Reduced uptake by glutamate transporters (EAATs), synaptic

In excitotoxicity, nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters such as glutamate become pathologically high, resulting in excessive stimulation of receptors. For example, when glutamate receptors such as the NMDA receptor or AMPA receptor encounter excessive levels of the excitatory neurotransmitter, glutamate, significant neuronal damage might ensue. Different mechanisms might lead to increased extracellular glutamate concentrations, e.g. reduced uptake by glutamate transporters (EAATs), synaptic hyperactivity, or abnormal release from different neural cell types. Excess glutamate allows high levels of calcium ions (Ca²⁺) to enter the cell. Ca²⁺ influx into cells activates a number of enzymes, including phospholipases, endonucleases, and proteases such as calpain. These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA. In evolved, complex adaptive systems such as biological life it must be understood that mechanisms are rarely, if ever, simplistically direct. For example, NMDA, in subtoxic amounts, can block glutamate toxicity and thereby induce neuronal survival.

The symbole, also called ar vuoc'h, was an object used by Francophone headmasters in public and private schools in Brittany, French Flanders, Occitania, Basque Country and North Catalonia as a means of punishment for students caught speaking Breton, Flemish, Occitan, Basque, or Catalan during the 19th and 20th centuries.

Rhosgoch is a small village in the north of the island of Anglesey, Wales, about 3.5 miles (5.6 km) to the south-west of Amlwch. It is in the community of Rhosybol.